Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure

Author:

Dugaich Adriana P. Castilho1,Oliveira-Sales Elizabeth B.1,Abreu Nayda P.2,Boim Mirian A.2,Bergamaschi Cássia T.1,Campos Ruy R.3

Affiliation:

1. Cardiovascular Division, Department of Physiology, Federal University of São Paulo, São Paulo, SP, Brazil

2. Nephrology Division, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil

3. Cardiovascular Division, Department of Physiology, Federal University of São Paulo, Sao Paulo School of Medicine, Rua Botucatu, 862, 04023-060 Sao Paulo, SP, Brazil

Abstract

Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension. In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is an important mechanism leading to hypertension in CRF. In CRF rats we found an increase in the abundance of p47phoxand gp91phoxmRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C). Tempol but not candesartan into the RVLM decreased MAP in CRF but not in C rats. GABA into the RVLM decreased MAP in CRF (63±8 mmHg) more intensely than in C (33±3 mmHg). The results suggest that increased oxidative stress within the RVLM has an important participation to maintain hypertension in CRF rats apparently independently of AT1Ang II receptors.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Hindawi Limited

Subject

Internal Medicine

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