Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs

Abstract

The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n=10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's lactate solution and hydroxyethyl starch-based solution in a 2 : 1 ratio. The cardiac output was measured by Doppler echocardiography and blood pressure by oscillometric device, and posteriorly hemodynamic parameters were calculated. The anemic groups had increase in cardiac index(P<.05)(3.82±1.05to5.86±1.49and5.81±1.63 L/min × m2) and decreases(P<.05)in the indices of total peripheral resistance (6797.81±3060.22to3220.14±1275.02and3887.74±1394.89dina⋅seg/cm5 × m2) and oxygen delivery (7942.84±3344.00to4021.68±1627.00and4430.82±1402.61 mL/min × m2), respectively. There were no significant changes in pH, but PaO2and SaO2values were increased, and PaCO2reduced in anemic dogs(P<.05). Therefore, acute normovolemic anemia can create significant hemodynamic changes and despite some hemogasometric changes, there were no changes in the acid-base status in dogs.