Clinical features of sporadic multigland parathyroid disease

Abstract

Background. Sporadic multigland parathyroid disease (MGD) account for 1/4 of all cases of primary hyperparathyroidism (PHPT). There are no specific signs of MGD in comparison with single-gland parathyroid disease in PHPT. The only radical treatment is surgical, therefore, determining the number of excessively functioning parathyroid glands at the preoperative stage is important for choosing the extent of the operation and the success of the treatment in general.The aim. To identify the specific signs of multigland parathyroid disease in patients who underwent surgery for primary hyperparathyroidism. Methods. We conducted a single-center prospective study including 126 cases of surgical treatment of PHPT from December 2019 to June 2021. The study included an analysis of demographic, clinical, laboratory parameters and visual methods of topical diagnosis of parathyroid glands (ultrasound, scintigraphy, multislice computed tomography). The main endpoint of the study was the identification of characteristic signs of MGD in patients with PHPT.Results. Lower values of creatinine (p ≤ 0.01; Mann – Whitney U-test), albuminadjusted calcium (p ≤ 0.05; Mann – Whitney U-test), parathyroid hormone (p ≤ 0.01; Mann – Whitney U-test), glomerular filtration rate (p ≤ 0.01; Mann – Whitney U-test) and inconsistency of two methods of preoperative imaging (p ≤ 0.01; χ2) were set as specific signs of multigland compared with single-gland parathyroid disease. Conclusion. The results of preoperative biochemical and imaging studies can become the basis for differentiating single-gland and multigland parathyroid disease in primary hyperparathyroidism.