Studying of the anti-ischemic action of <I>Rhaponticum uniflorum</I> and <I>Serratula centauroides</I> dry extracts on a model of bilateral occlusion of the carotid arteries

Abstract

The aim of the study to evaluate the anti-ischemic effect of Serratula centauroides and Rhaponticum uniflorum dry extracts for bilateral carotid artery occlusion.Materials and methods. The studies were carried out on 77 Wistar rats. Rh. uniflorum and S. centauroides dry extracts at doses 50, 100, 200 mg/kg were administered intragastrically for 14 days prior to bilateral occlusion of the carotid arteries. To assess the anti-ischemic effect of the investigated agents, the total mortality, the dynamics of survival, the survival time, the animals’ neurological status were determined using a modified McGraw scale and the brain hydration degree.Results. S. centauroides at a dose 200 mg/kg reduced the percentage of animals’ death by 2.8 times (p ≤ 0.05) compared with the control. Life expectancy in animals treated with S. centauroides at doses 100 and 200 mg/kg and Rh. uniflorum at dose 100  mg/kg increased by 46, 52 and 64  %, respectively, compared to the control. The neurological deficit lowest severity was observed in animals treated with S. centauroides at dose 200 mg/kg. The most pronounced statistically significant decrease in the brain hydration level was observed in animals treated with Rh.  uniflorum at doses 100 and 200 mg/kg and S. centauroides at dose 100 mg/kg.Conclusion. S. centauroides and Rh. uniflorum dry extracts have an anti-ischemic effect in cerebral ischemia.