Affiliation:
1. Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment; Far Eastern Federal University, Medical Center
2. Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment
Abstract
Background. The study of the association of risk factors and atherosclerotic burden assessed by coronary angiography is promising in terms of both understanding the pathogenesis of the disease and predicting its development. The aim of the study was to investigate the relationship between traditional risk factors and the severity of coronary atherosclerosis in patients with stable CHD.Materials and methods. Risk factors were studied in 100 patients who underwent angiography. Based on the Gensini (GS) score, participants were divided into groups: patients with moderate lesion of coronary arteries (GS = 8–39), with severe lesion (GS ≥ 40), and control group (GS = 0). To verify the association between the variables, Pearson’s chi-square test was used. The results were presented as relative risk (RR) and the confidence interval (95% CI).Results. It was found that in patients with GS score less than 40 points, statistically significant factors were hypertension (RR = 2.6; 95% CI: 1.023–10.09; р = 0.018), family history (RR = 2.94; 95% CI: 1.501–5.762; р < 0.001), depression (RR = 1.81; 95% CI: 1.202–2.738; р = 0.028), In patients with GS ≥ 40, the most important factors were diabetes (RR = 1.72; 95% CI: 1.187–2.511; р = 0,017), family history (RR = 2.02; 95% CI: 1.233–3.315; р = 0.002), inactivity (RR = 1.85; 95% CI: 1.219–2.824; р = 0.005). The GS scores were significantly higher in smokers compared non-smokers (44.0 vs. 32.0; p = 0.043).Conclusion. The most significant influence on the development of coronary atherosclerosis is exerted by a family history and physical inactivity. Arterial hypertension and depression are associated with moderate coronary artery disease. Severe athero sclerosis is associated with diabetes mellitus, long smoking history, low levels of high-density lipoprotein cholesterol.
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology
Reference18 articles.
1. World Health Organization. The top 10 causes of death. 2018. URL: https://www.who.int/news-room/fact-sheets/detail/the-top10-causes-of-death [date of access: 15.03.2019].
2. Neglia D, Rovai D, Caselli C, Pietila M, Teresinska A, AguadéBruix S, et al.; EVINCI Study Investigators. Detection of significant coronary artery disease by non-invasive anatomical and functional imaging. Circ Cardiovasc Imaging. 2015; 8(3): e002179. doi: 10.1161/CIRCIMAGING.114.002179
3. Shalnova SA, Deev AD, Balanova YuA, Kapustina AV, Imaeva AE, Muromtseva GA, et al. Twenty years trends of obesity and arterial hypertension and their association in Russia. Cardiovascular Therapy and Prevention. 2017; 16(4): 4-10. (In Russ.). doi: 10.15829/1728-8800-2017-4-4-10
4. Balanova YuA, Shalnova SA, Deev AD, Kapustina AV, Konstantinov VV, Boytsov SA. Smoking prevalence in Russia. What has changed over 20 years? Profilakticheskaya meditsina. 2015; 18(6): 47-52. (In Russ.). doi: 10.17116/profmed201518647-52
5. Balanova IuA, Kontsevaia AV, Shalnova SA, Deev AD, Artamonova VG, Gatagonova TM, et al. Prevalence of behavioral risk factors for cardiovascular diseases in the Russian population: Results of the ESSE-RF epidemiological study. Profilakticheskaya meditsina. 2014; 17(5): 42-52. (In Russ.).