CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA-Reference-Cited by-同舟云学术

CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA

Published:2018-07-28 Issue:4 Volume:3 Page:53-60
ISSN:2587-9596
Container-title:Acta Biomedica Scientifica (East Siberian Biomedical Journal)
language:
Short-container-title:Acta biomedica scientifica

Author:

Kozlova I. V.¹,Demina T. V.²,Tkachev S. E.³,Doroshchenko E. K.¹,Lisak O. V.²,Verkhozina M. M.⁴,Karan L. S.⁵,Dzhioev Yu. P.⁶,Paramonov A. I.¹,Suntsova O. V.¹,Savinova Yu. S.¹,Chernoivanova O. O.¹,Ruzek D.⁷,Tikunova N. V.⁵,Zlobin V. I.⁶

Affiliation:

1. Scientific Сentre for Family Health and Human Reproduction Problems

2. Irkutsk State University of Agriculture

3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences

4. Center for Hygiene and Epidemiology in the Irkutsk Region

5. Central Research Institute of Epidemiology

6. Research Institute of Biomedical Technology of Irkutsk State Medical University

7. Veterinary Research Institute

Abstract

Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”. Therefore, for this original TBEV variant it was necessary to study the genetic, biological properties of the “group 886” strains, clarify its TBEV taxonomic status, its range, evolutionary history, etc.Aim. The generalization of the currently available data on genetic and biological properties of TBEV “886” group.Materials and methods. The genetic structure of “group 886” strains was studied by the complex of molecular-genetic methods (MHNA, sequencing of fragments or the complete genome).Results. It was shown that “group 886” strains form a separate cluster on phylogenetic tree, and the level of genetic differences from other genotypes is more than 12 %. It was defined that this TBEV variant has its own area (Irkutsk region, Republic of Buryatia, Trans-Baikal region, Northern Mongolia). Its ecological connection with all links of the transmissive chain (ixodid ticks, small mammals, human), participation in human pathology, stability and duration of circulation in the Baikal region, individual evolutionary history were proved. Some phenotypic characteristics of the “group 886” strains were considered.Conclusion. The presented data testify to the validity of the “886 group” isolation as an independent genetic type. Taking into account the geographical distribution of this TBEV genotype, we propose to assign it the name “Baikal genotype/subtype”.

Publisher

FSPSI SCFHHRP

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