Affiliation:
1. Samara State Medical University
2. Samara Diagnostic Center
Abstract
Against the background of priority attention paid to the COVID-19 pandemic, there are also cases of community-acquired pneumonia of a different genesis. Identification of the features of lung lesions in such diseases is relevant during the spread of seasonal respiratory infections. The comparative study of the dynamics of hematological and hemostasiological parameters of blood in patients with pneumonia of various origins is of interest in terms of searching for predictors of the prognosis of the diseases development.Aim. To compare the features of clinical symptoms, hematological and hemostasiological parameters in patients with pneumonia caused by COVID-19 and in patients with community-acquired pneumonia.Materials and methods. During cross-sectional study two groups were formed: group 1 consisted of 92 patients diagnosed with moderate community-acquired pneumonia caused by COVID-19 infection; group 2 included 40 patients diagnosed with moderate community-acquired bilateral polysegmental pneumonia.Results. It was found that patients with COVID-19 had an older age (69 vs 39.3 years), a lower body temperature at admission (37.5 vs 38.85 °C), a lower percentage of reduced oxygen saturation (less than 89 % in 5.4 % of cases vs 10 % of cases). In most cases, the average values of some hematological parameters in patients with COVID-19 did not go beyond the reference range. Leukopenia (below 4 × 109 cells/l) and lymphopenia (below 1.1 × 109 cells/l) were observed in 26 % and 38 % of cases respectively; thrombocytopenia (less than 100 × 109 cells/l) – in 12.2 % of cases; hyperfibrinogenemia (more than 4 g/l) – in 65.3 % of cases. A direct correlation was found between platelet levels and leukocytes (R = 0.53; p < 0.001) and lymphocytes (R = 0.29; p = 0.06). Compared with the patients of the group 2,on average, patients with COVID-19 had significantly lower levels of leukocytes and lymphocytes (2.5 times each; p < 0.001) and an increased level of fibrinogen (by 45 %; p < 0.001).Conclusion. In patients with pneumonia caused by COVID-19, we revealed the particular features of clinical symptoms, hematological and hemostasiological blood parameters compared to community-acquired nonspecific pneumonia.
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology
Reference29 articles.
1. Lvov DK, Alkhovsky SV, Kolobukhina LV, Burtseva EI. Etiology of the COVID-19 outbreak in Wuhan (Hubei Province, China) associated with the 2019-CoV virus (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, subgenus Sarbecovirus): Lessons from the SARS-CoV epidemic. Problems of Virology. 2020; 65(1): 6-15. doi: 10.36233/0507-4088-2020-65-1-6-15. (In Russ.)
2. Guo YR, Cao QD, Hong ZS, Tan YY, Shen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status. Mil Med Res. 2020; 7(1): 11. doi: 10.1186/s40779-020-00240-0
3. Kissova J, Bulikova A, Ovesna P, Bourkova L, Penka M. Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms. Int J Hematol. 2014; 100(5): 429-436. doi: 10.1007/s12185-014-1673-0
4. Abaturov AE, Agafonova EA, Krivusha EL, Nikulina AA. COVID-19 pathogenesis. Child’s Health. 2020; 15(2): 133-144. doi: 10.22141/2224-0551.15.2.2020.200598. (In Russ.)
5. Nikiforov VV, Suranova TG, Chernobrovkina TYa,Yankovskaya YaD, Burova SV. Novel coronavirus infection (COVID-19): Clinical and epidemiological aspects. The Russian Archives of Internal Medicine. 2020; 10(2): 87-93. doi: 10.20514/2226-6704-2020-102-87-93. (In Russ.)
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献