The impact of hypothyroidism and levothyroxine treatment on preeclampsia risk: unraveling the connection for improved maternal and neonatal outcomes

Abstract

Aims: Preeclampsia, a pregnancy-related complication, may develop in women with hypothyroidism. Possible risk factors may include comorbidities, predisposition to diabetes, obesity, advanced maternal age, and prior infertility treatments. The study aims to investigate the relationship between hypothyroidism and the risk of preeclampsia in pregnant women receiving levothyroxine by examining its application period. Methods: This is a retrospective cohort included pregnant women who gave birth between December 2022-April 2023. Women with 110 preeclampsia and those without preeclampsia (152 controls) were identified and compared in terms of hypothyroidism status, type of hypothyroidism, and levothyroxine treatment. Results: The results showed a significant association between the severity of the preeclampsia and its onset that early onset cases were more likely to be severe, while late onset cases were predominantly mild (p