Analysis of clinical findings and serum micronutrients in pediatric patients with nonalcoholic fatty liver disease

Abstract

Aim: Nonalcoholic fatty liver disease (NAFLD) is the hepatic finding of systemic lipid and energy metabolism disorder. NAFLD is frequently observed in people with higher body mass index. Serum micronutrient levels play an important role in hepatic metabolism. Material and Method: This study included 60 NAFLD and 66 control patients. . NAFLD and control groups were compared in terms of ultrasonography (USG) and shear wave elastography (SWE) results. The two groups were compared in serum lipid profile, aminotransferase, insulin, glucose, and HOMA-IR. Both groups were then analyzed in terms of serum ferritin, B12, and vitamin D levels.Results: . 35% (n=21) of the patients in the NAFLD group had grade 1, 55% (n=33) had grade 2 and 10% (n=6) had grade 3 adiposity. HOMA-IR and insulin levels were higher in the NAFLD group (p=0.02; p=0.001). While the serum ferritin level of the patients in the NAFLD group was higher than the control group (p=0.001); the B12 level was lower (p=0.006). In terms of vitamin D, there was no difference (p=0.368). Conclusion: It is essential to identify risk factors in children on follow-up due to NAFLD. USG and liver function tests remain the first option in the diagnosis and screening of NAFLD in children. Serum ferritin, B12, and vitamin D levels of children on follow-up due to NAFLD should be analyzed in consideration of liver fattening.