Affiliation:
1. Health Sciences University, Bursa Yüksek İhtisas Training and Research Hospital
2. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, BURSA YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Abstract
Aim: In this article, we aimed to contribute to the outcomes of the consanguineous marriage literature by analyzing fetal results in this population.
Material and Method: We included 185 patients in this retrospective research. Demographic, clinical, ultrasonographic and delivery data were received from electronic patient records. Also, we recorded the postnatal results, and findings of the infants. By combining all the data, we reported a descriptive analysis of the results of our consanguineous marriage cases with perinatology follow-up.
Results: We had 231 pregnant women in the study, and their mean age was 28.9 years. 117 (50.6%) of the pregnant women had first-degree, and 114 (50.4%) had second-degree consanguineous marriages. Fetal findings were evaluated as usual in 157 (68%) of the pregnant in the ultrasonographic scans performed between prenatal 20-24 weeks of gestation. When we look at the first postnatal examinations of the babies, no abnormal findings were in 134 babies (58.8%). Twenty-two infants (9.6%) were followed up in the neonatal intensive care unit with the diagnosis of transient tachypnea of the newborn, and phototherapy was required in 14 infants (6.1%) due to hyperbilirubinemia. The number of cases requiring surgical intervention after delivery or with significant life-threatening anomalies included 56 findings in 32 infants. There were spina bifida cases in 8 infants and hydrocephalus in 9 infants.
Conclusion: There was an increased level of congenital anomalies associated with consanguineous marriages. Health care centers should educate individuals regarding the negative role of cousin marriages leading to abnormalities in children.
Publisher
Journal of Health Sciences and Medicine
Reference21 articles.
1. Chauhan BG, Yadav D, Jungari S. Association between consanguineous marriage and child nutritional outcomes among currently married women in Pakistan. Clin Epidemiol Global Health 2020; 8: 38–44.
2. Naveed M, Nadeem S, Hassan A, Tanvir I. Association of consanguineous marriages with congenital anomalies: Cousin marriages and birth defects. Pakistan BioMedical J 2019; 2.
3. Abrar S, Safdar W, Hanif M, Shujaat N. Pregnancy outcomes of consanguinity among antenatal patients attending combined military hospital Quetta, Pakistan. J Ayub Medical College Abbottabad 2018; 30: 423–7.
4. Robertson JM, Basany K, Farooq F, et al. Consanguineous marriage and early pregnancy loss in rural to Peri-Urban India. J Obstetr Gynecol India 2022; 72: 314–21.
5. Hamamy H, Antonarakis SE, Cavalli-Sforza LL, et al. Consanguineous marriages, pearls and perils: Geneva international consanguinity workshop report. Genetics in Medicine 2011; 13: 841–7.