Usutu virus infection in a patient who underwent orthotropic liver transplantation, Italy, August-September 2009

Author:

Cavrini F12,Gaibani P21,Longo G3,Pierro A M2,Rossini G2,Bonilauri P4,Gerunda G E5,Di Benedetto F5,Pasetto A6,Girardis M6,Dottori M4,Landini M P2,Sambri V2

Affiliation:

1. These Authors contributed equally to this paper and are listed in alphabetical order

2. Clinical Microbiology Unit, Regional Reference Centre for Microbiological Emergencies – CRREM, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy

3. Oncology and Haematology Unit, Modena University Hospital, Modena, Italy

4. Experimental Institute for Animal Health and Protection of Lombardia and Emilia-Romagna, Brescia, Italy

5. Liver and Multivisceral Transplant Center, University of Modena and Reggio Emilia, Modena, Italy

6. Anaestesiology and Intensive Care Unit 1, Modena University Hospital, Modena, Italy

Abstract

We report a case of Usutu virus (USUV)-related illness in a patient that underwent an orthotropic liver transplant (OLT). Post transplant, the patient developed clinical signs of a possible neuroinvasive disease with a significant loss of cerebral functions. USUV was isolated in Vero E6 cells from a plasma sample obtained immediately before the surgery, and USUV RNA was demonstrated by RT-PCR and sequencing. This report enlarges the panel of emerging mosquito-borne flavivirus-related disease in humans.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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