Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid

Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results

Published:2015-02-05 Issue:5 Volume:20 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Pebody R G¹,Warburton F¹,Ellis J²,Andrews N¹,Thompson C²,von Wissmann B³,Green H K¹,Cottrell S⁴,Johnston J⁵,de Lusignan S⁶,Moore C⁷,Gunson R⁸,Robertson C⁹¹⁰,McMenamin J³,Zambon M²

Affiliation:

1. Public Health England Centre of Infectious Disease Surveillance and Control, London, United Kingdom

2. Public Health England Operations Directorate, Microbiology Services, Colindale, London, United Kingdom

3. Health Protection Scotland, Glasgow, United Kingdom

4. Public Health Wales, Cardiff, United Kingdom

5. Public Health Agency Northern Ireland, Belfast, United Kingdom

6. Royal College of General Practitioners Research and Surveillance Centre, United Kingdom

7. Public Health Wales Molecular Diagnostics Unit, Cardiff, United Kingdom

8. West of Scotland Specialist Virology Centre, Glasgow, United Kingdom

9. University of Strathclyde, Glasgow, United Kingdom

10. International Prevention Research Institute, Lyon, France

Abstract

In 2014/15 the United Kingdom experienced circulation of influenza A(H3N2) with impact in the elderly. Mid-season vaccine effectiveness (VE) shows an adjusted VE of 3.4% (95% CI: ?44.8 to 35.5) against primary care consultation with laboratory-confirmed influenza and ?2.3% (95% CI: ?56.2 to 33.0) for A(H3N2). The low VE reflects mismatch between circulating viruses and the 2014/15 northern hemisphere A(H3N2) vaccine strain. Early use of antivirals for prophylaxis and treatment of vulnerable populations remains important.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference18 articles.

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2. Public Health England (PHE). PHE Weekly National Influenza Report – week 4 report. London: PHE. 22 Jan 2015. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/397454/Weekly_report_current_week_4x.pdf

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