Mutations acquired during cell culture isolation may affect antigenic characterisation of influenza A(H3N2) clade 3C.2a viruses-Reference-Cited by-同舟云学术

Mutations acquired during cell culture isolation may affect antigenic characterisation of influenza A(H3N2) clade 3C.2a viruses

Published:2016-01-21 Issue:3 Volume:21 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Skowronski Danuta M¹²,Sabaiduc Suzana¹,Chambers Catharine¹,Eshaghi Alireza³,Gubbay Jonathan B³⁴,Krajden Mel¹²,Drews Steven J⁵⁶,Martineau Christine⁷,De Serres Gaston⁷⁸⁹,Dickinson James A¹⁰,Winter Anne-Luise³,Bastien Nathalie¹¹,Li Yan¹¹¹²

Affiliation:

1. British Columbia Centre for Disease Control, Vancouver, Canada

2. University of British Columbia, Vancouver, Canada

3. Public Health Ontario, Toronto, Canada

4. University of Toronto, Toronto, Canada

5. University of Alberta, Edmonton, Canada

6. Alberta Provincial Laboratory, Edmonton, Canada

7. Institut National de Santé Publique du Québec (National Institute of Health of Quebec), Quebec, Canada

8. Laval University, Quebec, Canada

9. Centre Hospitalier Universitaire de Québec (University Hospital Centre of Quebec), Quebec, Canada

10. University of Calgary, Calgary, Canada

11. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

12. University of Manitoba, Winnipeg, Canada

Abstract

As elsewhere, few (< 15%) sentinel influenza A(H3N2) clade 3C.2a viruses that dominated in Canada during the 2014/15 season could be antigenically characterised by haemagglutination inhibition (HI) assay. Clade 3C.2a viruses that could be HI-characterised had acquired genetic mutations during in vitro cell culture isolation that modified the potential glycosylation motif found in original patient specimens and the consensus sequence of circulating viruses at amino acid positions 158–160 of the haemagglutinin protein. Caution is warranted in extrapolating antigenic relatedness based on limited HI findings for clade 3C.2a viruses that continue to circulate globally.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference20 articles.

1. Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada’s Sentinel Physician Surveillance Network, January 2015.;Skowronski;Euro Surveill,2015

2. Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines.;Ndifon;Proc Natl Acad Sci USA,2009

3. Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses.;Popova;PLoS ONE,2012

4. Glycosylation analysis of engineered H3N2 influenza A virus hemagglutinins with sequentially added historically relevant glycosylation sites.;An;J Proteome Res,2015

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