Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018-Reference-Cited by-同舟云学术

Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018

Published:2019-01-10 Issue:2 Volume:24 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Berger Anja¹²³,Dangel Alexandra¹²,Schober Tilmann⁴¹,Schmidbauer Birgit⁵,Konrad Regina²³,Marosevic Durdica²,Schubert Sören⁶,Hörmansdorfer Stefan²,Ackermann Nikolaus²,Hübner Johannes¹⁴,Sing Andreas¹²³

Affiliation:

1. These authors contributed equally to this paper

2. Bavarian Health and Food Safety Authority, Oberschleißheim, Germany

3. National Consiliary Laboratory for Diphtheria, Oberschleißheim, Germany

4. Division of Pediatric Infectious Diseases, Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany

5. Department of Health and Environment, Munich, Germany

6. Max von Pettenkofer-Institute, Ludwig-Maximilians-University Munich, Munich, Germany

Abstract

In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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