Application in Europe of a urine-based rapid diagnostic test for confirmation of Schistosoma mansoni infection in migrants from endemic areas

Author:

Becker S L123,Marti H42,Zimmermann S5,Vidacek D5,Herrmann M1,Utzinger J23,Schnabel P A6,Bohle R M6

Affiliation:

1. Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany

2. University of Basel, Basel, Switzerland

3. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland

4. Department of Medical Services and Diagnostic, Swiss Tropical and Public Health Institute, Basel, Switzerland

5. Department of Medicine II, Saarland University, Homburg/Saar, Germany

6. Institute of Pathology, Saarland University, Homburg/Saar, Germany

Abstract

In February 2015, a male patient from Eritrea with persistent abdominal pain and rectal bleeding was diagnosed with Schistosoma mansoni infection upon examination of a rectal biopsy. In May 2015, repeated stool microscopy identified S. mansoni infection in another Eritrean patient with abdominal pain and considerable eosinophilia (34%). Use of point-of-care circulating cathodic antigen (POC-CCA) tests on urine confirmed S. mansoni infection in both patients. Wider application of non-invasive POC-CCA urine tests will improve schistosomiasis diagnosis and clinical management in migrants.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference21 articles.

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2. Deutsche Gesellschaft für Tropenmedizin und Internationale Gesundheit (DTG). S1-Leitlinie: Diagnostik und Therapie der Schistosomiasis (Bilharziose). [S1 guideline : diagnosis and treatment of schistosomiasis (bilharzia)]. Version 07/2013. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) online; July 2013. German. Available from: http://www.awmf.org/uploads/tx_szleitlinien/042-005l_S1_Diagnostik_Therapie_Schistosomiasis_2013-07.pdf

3. Utzinger J, Becker SL, Knopp S, Blum J, Neumayr AL, Keiser J, et al. Neglected tropical diseases: diagnosis, clinical management, treatment and control. Swiss Med Wkly. 2012;142:w13727. 10.4414/smw.2012.13727 PMID:23180107

4. Human schistosomiasis

5. Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis

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