Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019-Reference-Cited by-同舟云学术

Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019

Published:2019-12-12 Issue:50 Volume:24 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Haller Sebastian¹,Kramer Rolf¹,Becker Karsten²,Bohnert Jürgen A²,Eckmanns Tim¹,Hans Jörg B³,Hecht Jane¹,Heidecke Claus-Dieter²,Hübner Nils-Olaf²,Kramer Axel²,Klaper Kathleen⁴,Littmann Martina⁵,Marlinghaus Lennart³,Neumann Bernd⁴,Pfeifer Yvonne⁴,Pfennigwerth Niels³,Rogge Simone⁵,Schaufler Katharina⁶,Thürmer Andrea⁷,Werner Guido⁴,Gatermann Sören³

Affiliation:

1. Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany

2. University Medicine Greifswald, Greifswald, Germany

3. National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany

4. Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany

5. Regional Public Health Authority Mecklenburg-Western Pomerania, Rostock, Germany

6. Institute of Pharmacy, University of Greifswald, Greifswald, Germany

7. Robert Koch Institute, Genome Sequencing Unit, Berlin, Germany

Abstract

From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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