Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016-Reference-Cited by-同舟云学术

Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016

Published:2016-06-16 Issue:24 Volume:21 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Takashita Emi¹,Fujisaki Seiichiro¹,Shirakura Masayuki¹,Nakamura Kazuya¹,Kishida Noriko¹,Kuwahara Tomoko¹,Shimazu Yukie²,Shimomura Takeshi³,Watanabe Shinji¹,Odagiri Takato¹,

Affiliation:

1. Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Center for Public Health and Environment, Hiroshima Prefectural Technology Research Institute, Hiroshima, Japan

3. Hiroshima Nishi Medical Center, Hiroshima, Japan

Abstract

An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference19 articles.

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