High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses

Author:

Huzly Daniela1,Hanselmann Ingeborg1,Schmidt-Chanasit Jonas23,Panning Marcus1

Affiliation:

1. Institute for Virology, Medical Center – University of Freiburg, Freiburg, Germany

2. Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Hamburg, Germany

3. German Centre for Infection Research (DZIF), partner site Hamburg-Luebeck-Borstel, Hamburg, Germany

Abstract

The current Zika virus (ZIKV) epidemic in the Americas caused an increase in diagnostic requests in European countries. Here we demonstrate high specificity of the Euroimmun anti-ZIKV IgG and IgM ELISA tests using putative cross-reacting sera of European patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis C virus. This test may aid in counselling European travellers returning from regions where ZIKV is endemic.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference14 articles.

1. First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013.;Tappe;Euro Surveill,2014

2. Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.;Brasil;N Engl J Med,2016

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