Detection of macrolide resistant Mycoplasma pneumoniae in England, September 2014 to September 2015

Author:

Brown Rebecca J12,Macfarlane-Smith Louissa3,Phillips Sarah1,Chalker Victoria J1

Affiliation:

1. Bacteriology Reference Department, Public Health England (PHE), London, United Kingdom

2. Cardiff University School of Medicine, Department of Child Health, University Hospital of Wales, Cardiff, United Kingdom

3. Department of Microbiology, Leeds General Infirmary, Leeds, United Kingdom

Abstract

Mycoplasma pneumoniae infection can cause pneumonia, particularly in children. Global increase in macrolide-resistant M. pneumoniae is of concern due to limited therapeutic options. We describe the detection of macrolide resistance-conferring mutations in 9.3% of 43 clinical specimens where M. pneumoniae was detected in England and Wales from September 2014‒September 2015. This study aims to impact by highlighting the presence of macrolide resistance in M. pneumoniae positive patients, promoting increased clinical vigilance.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference22 articles.

1. Macrolide resistant Mycoplasma pneumoniae in England and Wales: Abstract P724, 22nd European Congress of Clinical Microbiology and Infectious Diseases.;Chalker;Clin Microbiol Infect,2012

2. Clinical outcomes and macrolide resistance in Mycoplasma pneumoniae infection in Scotland, UK.;Ferguson;J Med Microbiol,2013

3. Emerging macrolide resistance in Mycoplasma pneumoniae in children: detection and characterization of resistant isolates.;Li;Pediatr Infect Dis J,2009

4. Mycoplasma pneumoniae and respiratory virus infections in children with persistent cough in England: a retrospective analysis.;Wang;Pediatr Infect Dis J,2011

5. Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia.;Narita;J Infect Chemother,2010

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