Cluster of human parechovirus infections as the predominant cause of sepsis in neonates and infants, Leicester, United Kingdom, 8 May to 2 August 2016

Author:

Tang Julian W12,Holmes Christopher W2,Elsanousi Fadwa A2,Patel Ayushi2,Adam Fazila2,Speight Rachel3,Shenoy Savitha3,Bronnert Daniel3,Stiefel Gary3,Sundaram Premkumar3,Pande Suchandra3,Sridhar Arani3,Kairamkonda Venkatesh3,Bandi Srini3

Affiliation:

1. Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

2. Clinical Microbiology and Virology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

3. Leicester Childrens Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

Abstract

We report an unusually high number of cases (n = 26) of parechovirus infections in the cerebrospinal fluid (CSF) of neonates and infants admitted with sepsis in the United Kingdom during 8 May to 2 August 2016. Although such infections in neonates and infants are well-documented, parechovirus has not been routinely included in many in-house and commercial PCR assays for CSF testing. Clinicians should consider routine parechovirus testing in young children presenting with sepsis.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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