2023/24 mid-season influenza and Omicron XBB.1.5 vaccine effectiveness estimates from the Canadian Sentinel Practitioner Surveillance Network (SPSN)

Author:

Skowronski Danuta M12,Zhan Yuping2,Kaweski Samantha E2,Sabaiduc Suzana2,Khalid Ayisha2,Olsha Romy3,Carazo Sara4,Dickinson James A5,Mather Richard G63,Charest Hugues4,Jassem Agatha N2,Levade Inès4,Hasso Maan3,Zelyas Nathan7,Gao Ruimin8,Bastien Nathalie8

Affiliation:

1. University of British Columbia, Vancouver, Canada

2. British Columbia Centre for Disease Control, Vancouver, Canada

3. Public Health Ontario, Toronto, Canada

4. Institut National de Santé Publique du Québec, Québec, Canada

5. University of Calgary, Calgary, Canada

6. Queen’s University, Kingston, Canada

7. Public Health Laboratory, Alberta Precision Laboratories, Edmonton, Canada

8. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

Abstract

The Canadian Sentinel Practitioner Surveillance Network reports mid-season 2023/24 influenza vaccine effectiveness (VE) of 63% (95% CI: 51–72) against influenza A(H1N1)pdm09, lower for clade 5a.2a.1 (56%; 95% CI: 33–71) than clade 5a.2a (67%; 95% CI: 48–80), and lowest against influenza A(H3N2) (40%; 95% CI: 5–61). The Omicron XBB.1.5 vaccine protected comparably well, with VE of 47% (95% CI: 21–65) against medically attended COVID-19, higher among people reporting a prior confirmed SARS-CoV-2 infection at 67% (95% CI: 28–85).

Publisher

European Centre for Disease Control and Prevention (ECDC)

Reference33 articles.

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2. National Influenza Annual Report, Canada, 2022-2023: Canada’s first fall epidemic since the 2019-2020 season.;Schmidt;Can Commun Dis Rep,2023

3. The test-negative design: validity, accuracy and precision of vaccine efficacy estimates compared to the gold standard of randomised placebo-controlled clinical trials.;De Serres;Euro Surveill,2013

4. Government of Canada. COVID-19 vaccines: Canadian immunization guide. Ottawa: Government of Canada. [Accessed: 29 Jan 2024]. Available from: https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-26-covid-19-vaccine.html#t1

5. World Health Organization (WHO). Recommended composition of influenza virus vaccines for use in the 2023-2024 northern hemisphere influenza season, Geneva: WHO; 2023. Available from: https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2023-2024-northern-hemisphere-influenza-season

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