Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022-Reference-Cited by-同舟云学术

Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Published:2022-08-04 Issue:31 Volume:27 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Romaní Vidal Adriana¹,Vaughan Aisling²,Innocenti Francesco³¹,Colombe Soledad²,Nerlander Lina¹,Rachwal Natalia¹,Ciancio Bruno Christian¹,Mougkou Aikaterini¹,Carvalho Carlos¹,Delgado Enrique¹,Mook Piers²,de Muylder Géraldine⁴,Peeters Michael⁵,Tenev Tencho⁶,Golkocheva-Markova Elitsa⁶,Vorobieva Solholm Jensen Veronika⁷,Koch Anders⁸,Figoni Julie⁹,Brouard Cécile⁹,Nikolopoulou Georgia¹⁰,Zisouli Anastasia¹⁰,Murphy Niamh¹¹,Broderick Annemarie¹²,Goldberg Lital¹³,Rich Rivka¹³,Hecht Sagie Lior¹³,Tosti Maria Elena¹⁴,Suligoi Barbara¹⁵,Joosten Rosa¹⁶,Pijnacker Roan¹⁶,Fjeldheim Ingvild¹⁷,Heen Eli¹⁷,Stępień Małgorzata¹⁸,Polański Piotr¹⁸,Tato Marinho Rui¹⁹,Vieira Martins João²⁰,Varela Carmen²¹,Avellón Ana²²,Andersson Emmi²³,Jansson Mörk Marie²³,Mandal Sema²⁴,Watson Conall²⁴,Coughlan Laura²⁴,Chand Meera²⁵,Neill Claire²⁶,Bradley Declan T²⁶,Li Kathy²⁷,O’Leary Maureen²⁸,McInnes Neil²⁹,Williams Christopher J³⁰,Moore Catherine³⁰,Gjini Ardiana³⁰,Duffell Erika¹,Pebody Richard²

Affiliation:

1. European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden

2. World Health Organization Regional Office for Europe, Copenhagen, Denmark

3. Epidemiology Unit, Regional Health Agency of Tuscany, Florence, Italy

4. Sciensano, Epidemiology of Infectious Diseases, Brussels, Belgium

5. Sciensano, Infectious Diseases in Humans, Viral Diseases, National Reference Centre for Hepatitis Viruses, Brussels, Belgium

6. National Reference Laboratory Hepatitis viruses, NCIPD-Virology, Sofia, Bulgaria

7. Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark

8. Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark

9. Santé Publique France, the National Public Health Agency, Saint-Maurice, France

10. Greek National Public Health Organization (EODY), Athens, Greece

11. Health Service Executive HPSC surveillance scientist on the National IMT for hepatitis, Dublin, Ireland

12. Children’s Health Ireland (CHI), Crumlin, Ireland

13. Israel Ministry of Health, Jerusalem, Israel

14. National Centre for Global Health - Istituto Superiore di Sanità, Rome, Italy

15. Infectious Disease Department - Istituto Superiore di Sanità, Rome, Italy

16. National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands

17. Department of Infection Control and Vaccines, Norwegian Institute of Public Health, Oslo, Norway

18. Department of Epidemiology of Infectious Diseases and Surveillance, National Institute of Public Health NIH – National Research Institute, Warsaw, Poland

19. Gastroenterology and Hepatology Department, Hospital S. Maria; Medical School of Lisbon; National Programme for Viral Hepatitis, Portugal Ministry of Health, Lisbon, Portugal

20. Directorate of Information and Analysis, Directorate-General of Health, Lisbon, Portugal

21. National Centre of Epidemiology, Carlos III Institute of Health, CIBERESP, Madrid, Spain

22. National Centre of Microbiology, Carlos III Institute of Health, CIBERESP, Madrid, Spain

23. Public Health Agency of Sweden, Solna, Sweden

24. United Kingdom Health Security Agency Epidemiology Cell, London, United Kingdom

25. United Kingdom Health Security Agency Incident Director, London, United Kingdom

26. Public Health Agency Northern Ireland, Belfast, United Kingdom

27. Regional Virology Laboratory Belfast Health and Social Care Trust, Northern Ireland, Belfast, United Kingdom

28. Clinical and Protecting Health Directorate, Public Health Scotland, Glasgow, United Kingdom

29. West of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom

30. Public Health Wales, Cardiff, United Kingdom

Abstract

Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3% were 5 years or younger and 53.5% had a positive test for adenovirus, 10.4% had a positive RT-PCR for SARS-CoV-2 and 10.3% were coinfected with both pathogens. Cases with adenovirus infections were significantly more likely to be admitted to intensive care or high-dependency units (OR = 2.11; 95% CI: 1.18–3.74) and transplanted (OR = 3.36; 95% CI: 1.19–9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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