Vaccine-induced and naturally-acquired protection against Omicron and Delta symptomatic infection and severe COVID-19 outcomes, France, December 2021 to January 2022

Author:

Suarez Castillo Milena12ORCID,Khaoua Hamid1,Courtejoie Noémie1ORCID

Affiliation:

1. The Health and Solidarity Ministerial Statistical Department (DREES), Paris, France

2. French national institute for statistical and economic studies (INSEE), Montrouge, France

Abstract

We assessed the protection conferred by naturally-acquired, vaccine-induced and hybrid immunity during the concomitant Omicron and Delta epidemic waves in France on symptomatic infection and severe COVID-19. The greatest levels of protection against both variants were provided by hybrid immunity. Protection against Omicron symptomatic infections was systematically lower and waned at higher speed than against Delta in those vaccinated. In contrast, there were little differences in variant-specific protection against severe inpatient outcomes in symptomatic individuals.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference14 articles.

1. Santé publique France (SPF). COVID-19 - Point épidémiologique hebdomadaire du 23 décembre 2021. [COVID-19 weekly epidemiological report of 23 December 2021]. Saint-Maurice: SPF. 23 Dec 2021. French. Available from: https://www.santepubliquefrance.fr/content/download/400096/3305200

2. European Centre for Disease Prevention and Control (ECDC). Reinfection with SARS-CoV-2: implementation of a surveillance case definition within the EU/EEA. 8 April 2021. ECDC: Stockholm, 2021. Available from: https://www.ecdc.europa.eu/en/publications-data/reinfection-sars-cov-2-implementation-surveillance-case-definition-within-eueea

3. Vaccine effectiveness and duration of protection against symptomatic and severe Covid-19 during the first year of vaccination in France;Suarez Castillo;MedRxiv,2022

4. SARS-CoV-2 reinfections: Overview of efficacy and duration of natural and hybrid immunity.;Pilz;Environ Res,2022

5. Covid-19 vaccine effectiveness against the omicron (B. 1.1. 529) variant.;Andrews;N Engl J Med,2022

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