Influenza vaccine effectiveness against A(H3N2) during the delayed 2021/22 epidemic in Canada

Author:

Kim Shinhye1,Chuang Erica SY1,Sabaiduc Suzana1,Olsha Romy2,Kaweski Samantha E1,Zelyas Nathan3,Gubbay Jonathan B42,Jassem Agatha N51,Charest Hugues6,De Serres Gaston786,Dickinson James A9,Skowronski Danuta M51

Affiliation:

1. British Columbia Centre for Disease Control, Vancouver, Canada

2. Public Health Ontario, Toronto, Canada

3. Public Health Laboratory, Alberta Precision Laboratories, Edmonton, Canada

4. University of Toronto, Toronto, Canada

5. University of British Columbia, Vancouver, Canada

6. Institut national de santé publique du Québec, Québec, Canada

7. Centre Hospitalier Universitaire de Québec, Québec, Canada

8. Laval University, Quebec, Canada

9. University of Calgary, Calgary, Canada

Abstract

Influenza virus circulation virtually ceased in Canada during the COVID-19 pandemic, re-emerging with the relaxation of restrictions in spring 2022. Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network reports 2021/22 vaccine effectiveness of 36% (95% CI: −38 to 71) against late-season illness due to influenza A(H3N2) clade 3C.2a1b.2a.2 viruses, considered antigenically distinct from the 3C.2a1b.2a.1 vaccine strain. Findings reinforce the World Health Organization’s decision to update the 2022/23 northern hemisphere vaccine to a more representative A(H3N2) clade 3C.2a1b.2a.2 strain.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference15 articles.

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3. Effects of confounding bias in coronavirus disease 2019 (COVID-19) and influenza vaccine effectiveness test-negative designs due to correlated influenza and COVID-19 vaccination behaviors.;Doll;Clin Infect Dis,2022

4. Canadian Influenza Sentinel Practitioner Surveillance Network (SPSN). Influenza vaccine effectiveness estimates % (95% CI), 2004-05 to 2018-19 seasons. Vancouver: British Columbia Centre for Disease Control. [Accessed: 6 September 2022]. Available from: http://www.bccdc.ca/resource-gallery/Documents/Statistics%20and%20Research/Publications/Epid/Influenza%20and%20Respiratory/SPSN_VE_By_Year_Table.pdf

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