COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022-Reference-Cited by-同舟云学术

COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022

Published:2022-07-28 Issue:30 Volume:27 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Kliker Limor¹²,Zuckerman Neta²,Atari Nofar²,Barda Noam³,Gilboa Mayan³,Nemet Ital²,Abd Elkader Bayan²,Fratty Ilana S⁴²,Jaber Hanaa³,Mendelson Ella¹²,Alroy-Preis Sharon⁴,Kreiss Yitshak³,Regev-Yochay Gili³¹,Mandelboim Michal¹²

Affiliation:

1. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

2. Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Tel-Hashomer, Israel

3. Sheba Medical Center, Tel-Hashomer, Israel

4. Public Health Services, Ministry of Health, Jerusalem, Israel

Abstract

This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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