Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021-Reference-Cited by-同舟云学术

Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021

Published:2021-09-16 Issue:37 Volume:26 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Blanquart François¹,Abad Clémence²,Ambroise Joëvin³,Bernard Mathieu⁴,Cosentino Gina³⁵,Giannoli Jean-Marc⁶,Débarre Florence⁷

Affiliation:

1. Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France*

2. LBM BIOESTEREL–Biogroup–Plateau technique de Mouans-Sartoux, Mouans-Sartoux, France

3. BPO-BIOEPINE–Biogroup–Plateau technique Chocolaterie, Levallois-Perret, France

4. BIOLITTORAL – Biogroup – Plateau technique la Bastide, Sanary sur Mer, France

5. UMR1173 INSERM, Université Paris-Saclay–UVSQ, Montigny-le-Bretonneux, France

6. DYOMEDEA-NEOLAB-Biogroup – Plateau technique de la Sauvegarde, Lyon, France

7. Institute of Ecology and Environmental Sciences of Paris (iEES-Paris, UMR 7618), CNRS, Sorbonne Université, UPEC, IRD, INRAE, 75252 Paris, France

Abstract

We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10−6). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: −3.32; 95% CI: −4.38 to −2.25; p < 10−6).

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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