Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022-Reference-Cited by-同舟云学术

Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022

Published:2022-05-12 Issue:19 Volume:27 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

de Kleine Ruben H¹²^ORCID,Lexmond Willem S³¹,Buescher Gustav⁴¹,Sturm Ekkehard⁵¹,Kelly Deidre⁶¹,Lohse Ansgar W⁴¹,Lenz Dominic⁷¹^ORCID,Hørby Jørgensen Marianne⁸¹,

Affiliation:

1. European Reference Network for hepatological diseases (ERN RARE-LIVER)

2. Department of Surgery, Division of Hepatobiliairy Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands

3. Department of Paediatrics, Division of Gastroenterology and Hepatology, Beatrix Children’s Hospital, University of Groningen, Groningen, The Netherlands

4. Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

5. Paediatric Gastroenterology/ Hepatology, University Hospital Tuebingen, Tuebingen, Germany

6. University of Birmingham, and The Liver Unit, Birmingham Women & Children’s Hospital, Birmingham, UK

7. Division of Neuropaediatrics and Paediatric Metabolic Medicine, Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

8. Department of Paediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark

Abstract

To detect potential concern about severe acute hepatitis in children, we conducted a survey among 50 ERN RARE-LIVER centres. By 26 April 2022, 34 centres, including 25 transplant centres, reported an estimated median of 3–5, 0–2 and 3–5 cases in 2021, 2020 and 2019 and a mean of 2 (range: 0–8) cases between January and April 2022 (mean in 10 large liver transplant centres: 3). Twelve centres reported suspicion of an increase, but no rise.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference11 articles.

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2. European Centre for Disease Prevention and Control (ECDC). Increase in severe acute hepatitis cases of unknown aetiology in children. Stockholm: ECDC; 28 Apr 2022. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/RRA-20220420-218.pdf

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