Effectiveness of bivalent mRNA booster vaccination against SARS-CoV-2 Omicron infection, the Netherlands, September to December 2022

Author:

Huiberts Anne J1,de Gier Brechje1,Hoeve Christina E1,de Melker Hester E1,Hahné Susan JM1,den Hartog Gerco21,van de Wijgert Janneke HHM31,van den Hof Susan1,Knol Mirjam J1

Affiliation:

1. Centre for Infectious Disease Control, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands

2. Radboud Centre for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands

3. Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht (UMCU), Utrecht, the Netherlands

Abstract

We used data of 32,542 prospective cohort study participants who previously received primary and one or two monovalent booster COVID-19 vaccinations. Between 26 September and 19 December 2022, relative effectiveness of bivalent original/Omicron BA.1 vaccination against self-reported Omicron SARS-CoV-2 infection was 31% in 18–59-year-olds and 14% in 60–85-year-olds. Protection of Omicron infection was higher than of bivalent vaccination without prior infection. Although bivalent booster vaccination increases protection against COVID-19 hospitalisations, we found limited added benefit in preventing SARS-CoV-2 infection.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference13 articles.

1. World Health Organization (WHO). One year since the emergence of COVID-19 virus variant Omicron. Geneva: WHO; 2022. Available from: https://www.who.int/news-room/feature-stories/detail/one-year-since-the-emergence-of-omicron

2. European Medicines Agency (EMA). First adapted COVID-19 booster vaccines recommended for approval in the EU. EMA; 2022. Available from: https://www.ema.europa.eu/en/news/first-adapted-covid-19-booster-vaccines-recommended-approval-eu

3. Rijksinstituut voor Volksgezondheid en Milieu (RIVM). Varianten van het coronavirus SARS-CoV-2.[Variants of the coronavirus SARS-CoV-2]. Bilthoven: RIVM; 2023. Dutch. Available from: https://www.rivm.nl/coronavirus-covid-19/virus/varianten

4. Design and baseline description of an observational population-based cohort study on COVID-19 vaccine effectiveness in the Netherlands - The VAccine Study COvid-19 (VASCO);Huiberts;Research Square,2022

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