Persistent morbidity in Clade IIb mpox patients: interim results of a long-term follow-up study, Belgium, June to November 2022

Author:

Berens-Riha Nicole1ORCID,Bracke Stefanie1,Rutgers Jojanneke1,Burm Christophe1,Van Gestel Liesbeth1,Hens Matilde1,Kenyon Chris21,Bottieau Emmanuel1,Soentjens Patrick1,Brosius Isabel1,Van Esbroeck Marjan1,Vercauteren Koen1,van Griensven Johan1,van Dijck Christophe31,Liesenborghs Laurens31,

Affiliation:

1. Institute of Tropical Medicine, Antwerp, Belgium

2. University of Cape Town, Cape Town, South Africa

3. These authors contributed equally to this work and share last authorship.

Abstract

While mpox was well characterised during the 2022 global Clade IIb outbreak, little is known about persistent morbidity. We present interim results of a prospective cohort study of 95 mpox patients assessed 3–20 weeks post-symptom onset. Two-thirds of participants had residual morbidity, including 25 with persistent anorectal and 18 with genital symptoms. Loss of physical fitness, new-onset/worsened fatigue and mental health problems were reported in 36, 19 and 11 patients, respectively. These findings require attention by healthcare providers.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference17 articles.

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3. European Centre for Disease Prevention and Control (ECDC). Joint ECDC-WHO Regional Office for Europe Mpox Surveillance Bulletin: 18 January 2023. Stockholm: ECDC. [Accessed: 30 Jan 2023]. Available from: https://monkeypoxreport.ecdc.europa.eu

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