Mpox outbreak in France: epidemiological characteristics and sexual behaviour of cases aged 15 years or older, 2022

Author:

Krug Catarina123ORCID,Tarantola Arnaud13,Chazelle Emilie13,Fougère Erica3,Velter Annie43,Guinard Anne3,Souares Yvan3,Mercier Anna3,François Céline3,Hamdad Katia3,Tan-Lhernould Laetitia3,Balestier Anita3,Lahbib Hana3,Etien Nicolas3,Bernillon Pascale3,De Lauzun Virginie3,Durand Julien3,Fayad Myriam3,De Valk Henriette3,Beck François53,Che Didier3,Coignard Bruno3,Lot Florence63,Mailles Alexandra63,

Affiliation:

1. These first authors contributed equally to this article

2. ECDC Fellowship Program, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Solna, Sweden

3. Santé publique France, The French Public Health Agency, Saint-Maurice, France

4. Aix Marseille Univ, INSERM, IRD, Sciences Economiques et Sociales de la Santé & Traitement de l’Information Médicale (SESSTIM), Marseille, France

5. Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Inserm U1018, Université Paris-Saclay, Université Paris-Sud, Université Versailles Saint-Quentin (UVSQ), Villejuif, France

6. These authors contributed equally to this article

Abstract

Background Locally-acquired mpox cases were rarely reported outside Africa until May 2022, when locally-acquired-mpox cases occurred in various European countries. Aim We describe the mpox epidemic in France, including demographic and behavioural changes among a subset of cases, during its course. Methods Data were retrieved from the enhanced national surveillance system until 30 September 2022. Laboratory-confirmed cases tested positive for monkeypox virus or orthopoxviruses by PCR; non-laboratory-confirmed cases had clinical symptoms and an epidemiological link to a laboratory-confirmed case. A subset of ≥ 15-year-old male cases, notified until 1 August, was interviewed for epidemiological, clinical and sexual behaviour information. Association of symptom-onset month with quantitative outcomes was evaluated by t- or Wilcoxon tests, and with binary outcomes, by Pearson’s chi-squared or Fisher exact tests. Results A total of 4,856 mpox cases were notified, mostly in Île-de-France region (62%; 3,025/4,855). Cases aged ≥ 15 years were predominantly male (97%; 4,668/4,812), with 37 years (range: 15–81) as mean age. Between May and July, among the subset interviewed, mpox cases increased in regions other than Île-de-France, and mean age rose from 35 (range: 21–64) to 38 years (range: 16–75; p = 0.007). Proportions of cases attending men-who-have-sex-with-men (MSM) meeting venues declined from 60% (55/91) to 46% (164/359; p = 0.012); median number of sexual partners decreased from four (interquartile range (IQR): 1–10) to two (IQR: 1–4; p < 0.001). Conclusion Changes in cases’ characteristics during the epidemic, could reflect virus spread from people who were more to less behaviourally vulnerable to mpox between May and July, or MSM reducing numbers of sexual partners as recommended.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference32 articles.

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4. The changing epidemiology of human monkeypox-A potential threat? A systematic review.;Bunge;PLoS Negl Trop Dis,2022

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