SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines-Reference-Cited by-同舟云学术

SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines

Published:2020-06-25 Issue:25 Volume:25 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Barr Ian G¹²³^ORCID,Rynehart Cleve³,Whitney Paul²³,Druce Julian⁴

Affiliation:

1. Faculty of Science and Technology, Federation University, Gippsland, VIC, Australia

2. Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia

3. The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia

4. Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia

Abstract

The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen’s eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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