1. These authors contributed equally to this work
2. Aix Marseille University, IRD, AP-HM, MEPHI, Marseille, France
3. University Hospital Institute -Méditerranée Infection (IHU), Marseille, France
4. French National Public Health Agency (Santé publique France), Marseille, France
5. Regional Health Agency of Provence-Alpes-Côte d’Azur (ARS Paca), Marseille, France
6. Center for Studies and Research on Health Services and Quality of Life (CEReSS), Aix-Marseille University, Marseille, France
7. Service de Médecine Intensive - Réanimation, APHM, Hôpital Nord, Marseille, France
8. Hôpital Européen, SESSTIM, Aix-Marseille Univ, INSERM, IRD, Marseille, France
9. French National Public Health Agency (Santé publique France), Saint Maurice, France
10. Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France
11. National Reference Laboratory for pneumococcus, Créteil, France
12. Service des Urgences Adultes, Hôpital de la Timone, UMR MD2, Aix-Marseille Université, Marseille, France
13. Service des Urgences Adultes, Hôpital Nord, Marseille, France