Vaccine effectiveness against infection with the Delta (B.1.617.2) variant, Norway, April to August 2021

Author:

Seppälä Elina12,Veneti Lamprini3ORCID,Starrfelt Jostein3ORCID,Danielsen Anders Skyrud3ORCID,Bragstad Karoline4,Hungnes Olav4,Taxt Arne Michael2,Watle Sara Viksmoen2,Meijerink Hinta2

Affiliation:

1. ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control, (ECDC), Stockholm, Sweden

2. Department of infectious disease control and vaccines, Norwegian Institute of Public Health, Oslo, Norway

3. Department of infectious disease control and preparedness, Norwegian Institute of Public Health, Oslo, Norway

4. Department of virology, Norwegian Institute of Public Health, Oslo, Norway

Abstract

Some variants of SARS-CoV-2 are associated with increased transmissibility, increased disease severity or decreased vaccine effectiveness (VE). In this population-based cohort study (n = 4,204,859), the Delta variant was identified in 5,430 (0.13%) individuals, of whom 84 were admitted to hospital. VE against laboratory confirmed infection with the Delta variant was 22.4% among partly vaccinated (95% confidence interval (CI): 17.0−27.4) and 64.6% (95% CI: 60.6−68.2) among fully vaccinated individuals, compared with 54.5% (95% CI: 50.4−58.3) and 84.4% (95%CI: 81.8−86.5) against the Alpha variant.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference14 articles.

1. European Centre for Disease Prevention and Control (ECDC). SARS-CoV-2 variants of concern as of 15 July 2021. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/en/covid-19/variants-concern

2. European Centre for Disease Prevention and Control (ECDC). Threat assessment brief: implications for the EU/EEA on the spread of the SARS-CoV-2 Delta (B.1.617.2) variant of concern. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/en/publications-data/threat-assessment-emergence-and-impact-sars-cov-2-delta-variant

3. World Health Organization (WHO). Weekly epidemiological update on COVID-19 - 20 July 2021. Geneva: WHO; 2021. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---20-july-2021

4. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant.;Lopez Bernal;N Engl J Med,2021

5. SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness.;Sheikh;Lancet,2021

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