Molecular epidemiology of the SARS-CoV-2 variant Omicron BA.2 sub-lineage in Denmark, 29 November 2021 to 2 January 2022-Reference-Cited by-同舟云学术

Molecular epidemiology of the SARS-CoV-2 variant Omicron BA.2 sub-lineage in Denmark, 29 November 2021 to 2 January 2022

Published:2022-03-10 Issue:10 Volume:27 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Fonager Jannik¹^ORCID,Bennedbæk Marc¹^ORCID,Bager Peter²,Wohlfahrt Jan³,Ellegaard Kirsten Maren⁴,Ingham Anna Cäcilia⁴^ORCID,Edslev Sofie Marie⁴,Stegger Marc⁴^ORCID,Sieber Raphael Niklaus⁴^ORCID,Lassauniere Ria¹^ORCID,Fomsgaard Anders¹^ORCID,Lillebaek Troels⁵⁶^ORCID,Svarrer Christina Wiid⁴,Møller Frederik Trier⁷^ORCID,Møller Camilla Holten²^ORCID,Legarth Rebecca²,Sydenham Thomas Vognbjerg⁸^ORCID,Steinke Kat⁸^ORCID,Paulsen Sarah Juel⁹,Castruita José Alfredo Samaniego⁹^ORCID,Schneider Uffe Vest⁹,Schouw Christian Højte¹⁰,Nielsen Xiaohui Chen¹⁰,Overvad Maria⁷,Nielsen Rikke Thoft⁷,Marvig Rasmus L¹¹^ORCID,Pedersen Martin Schou¹²,Nielsen Lene¹³,Nilsson Line Lynge¹³,Bybjerg-Grauholm Jonas¹⁴^ORCID,Tarpgaard Irene Harder¹⁵,Ebsen Tine Snejbjerg¹⁵,Lam Janni Uyen Hoa⁷,Gunalan Vithiagaran¹^ORCID,Rasmussen Morten¹^ORCID

Affiliation:

1. Virus Research and Development Laboratory, Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark

2. Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark

3. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

4. Department of Bacteria, Parasites, and Fungi, Statens Serum Institut, Copenhagen, Denmark

5. Global Health Section, University of Copenhagen, Copenhagen, Denmark

6. International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark

7. Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark

8. Department of Clinical Microbiology, Odense University Hospital, Denmark

9. Department of Clinical Microbiology, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark

10. Department of Clinical Microbiology, Zealand University Hospital, Køge, Denmark

11. Center for Genomic Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

12. Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

13. Department of Clinical Microbiology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark

14. Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

15. Clinical Microbiology Department, Aarhus University Hospital, Aarhus, Denmark

Abstract

Following emergence of the SARS-CoV-2 variant Omicron in November 2021, the dominant BA.1 sub-lineage was replaced by the BA.2 sub-lineage in Denmark. We analysed the first 2,623 BA.2 cases from 29 November 2021 to 2 January 2022. No epidemiological or clinical differences were found between individuals infected with BA.1 versus BA.2. Phylogenetic analyses showed a geographic east-to-west transmission of BA.2 from the Capital Region with clusters expanding after the Christmas holidays. Mutational analysis shows distinct differences between BA.1 and BA.2.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference30 articles.

1. Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa.;Viana;Nature,2022

2. Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: A Danish cohort study.;Hansen;medRxiv,2021

3. World Health Organization (WHO). Classification of Omicron (B.1.1.529): SARS-CoV-2 variant of concern. Geneva: WHO; 26 Nov 2021. Available from: https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern#:~:text=Based%20on%20the%20evidence%20presented,as%20a%20VOC%2C%20named%20Omicron

4. Neutralization and stability of SARS-CoV-2 Omicron variant.;Zeng;bioRxiv,2021

5. Andrew R. Proposal to split B.1.1.529 to incorporate a newly characterised sibling lineage #361. Github. 7 Dec 2021. Available from: https://github.com/cov-lineages/pango-designation/issues/361

Cited by 73 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta;Immunity, Inflammation and Disease;2024-07

2. Computational analysis of affinity dynamics between the variants of SARS-CoV-2 spike protein (RBD) and human ACE-2 receptor;Virology Journal;2024-04-19

3. Computational analysis of affinity dynamics between the variants of SARS- CoV-2 spike protein (RBD) and human ACE-2 receptor;2024-03-20

4. Clinical Manifestations of Infections with the Omicron Sub-Lineages BA.1, BA.2, and BA.5: A Retrospective Follow-Up Analysis of Public Health Data from Mecklenburg-Western Pomerania, Germany;Viruses;2024-03-15

5. Paradigm of immune dysregulation in coronavirus disease-2019 infection;Exploration of Immunology;2024-01-31