Impact of booster vaccination on the control of COVID-19 Delta wave in the context of waning immunity: application to France in the winter 2021/22

Author:

Bosetti Paolo1,Tran Kiem Cécile21,Andronico Alessio1,Paireau Juliette31,Levy-Bruhl Daniel3,Alter Lise4,Fontanet Arnaud56,Cauchemez Simon1

Affiliation:

1. Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris, CNRS UMR2000, Paris, France

2. Collège Doctoral, Sorbonne Université, Paris, France

3. Santé publique France, French National Public Health Agency, Saint-Maurice, France

4. Haute Autorité de Santé, Saint-Denis la Plaine, France

5. PACRI Unit, Conservatoire National des Arts et Métiers, Paris, France

6. Emerging Diseases Epidemiology Unit, Institut Pasteur, Université de Paris, Paris, France

Abstract

Europe has experienced a large COVID-19 wave caused by the Delta variant in winter 2021/22. Using mathematical models applied to Metropolitan France, we find that boosters administered to ≥ 65, ≥ 50 or ≥ 18 year-olds may reduce the hospitalisation peak by 25%, 36% and 43% respectively, with a delay of 5 months between second and third dose. A 10% reduction in transmission rates might further reduce it by 41%, indicating that even small increases in protective behaviours may be critical to mitigate the wave.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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