Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023-Reference-Cited by-同舟云学术

Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

Published:2023-03-02 Issue:9 Volume:28 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Agergaard Charlotte Nielsen¹,Porsbo Lone Jannok²,Sydenham Thomas Vognbjerg¹,Hansen Sanne Grønvall Kjær¹,Steinke Kat¹,Larsen Sanne Løkkegaard¹,Helgason Kristján Orri³,Hansen Frank⁴,Karstensen Kasper Thystrup⁴,Henius Anna E⁴,Holzknecht Barbara Juliane⁵,Søes Lillian⁶,Schønning Kristian⁷,Wang Mikala⁸,Ank Nina⁹,Halldórsdóttir Anna Margrét¹⁰,Guðlaugsson Ólafur¹¹,Hammerum Anette M⁴,Kjerulf Anne²,Kristensen Brian²,Hasman Henrik⁴,Justesen Ulrik Stenz¹

Affiliation:

1. Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark

2. Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark

3. Department of Clinical Microbiology, Landspitali University Hospital of Iceland, Reykjavik, Iceland

4. Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark

5. Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark

6. Department of Clinical Microbiology, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark

7. Department of Clinical Microbiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

8. Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark

9. Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark

10. Centre for Health Security and Communicable Disease Control, Directorate of Health, Reykjavik, Iceland

11. Department of Internal Medicine, division of Infectious Diseases, Landspitali University Hospital of Iceland, Reykjavik, Iceland

Abstract

From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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