Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 – emergence of multiple antibiotic resistance calls for vigilance

Author:

Brooks Avril1,Lucidarme Jay2,Campbell Helen3,Campbell Laura1,Fifer Helen4,Gray Steve2,Hughes Gwenda4,Lekshmi Aiswarya2,Schembri Gabriel5,Rayment Michael6,Ladhani Shamez N73,Ramsay Mary E3,Borrow Ray2

Affiliation:

1. Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, United Kingdom

2. Meningococcal Reference Unit, Manchester Royal Infirmary, Public Health England, Manchester, United Kingdom

3. Immunisation and Countermeasures Division, Public Health England, London, United Kingdom

4. Blood Safety, Hepatitis, Sexually Transmitted Infections & HIV Division, Public Health England, London, United Kingdom

5. The Northern Integrated Contraception, Sexual Health & HIV Service, Manchester Royal Infirmary, Manchester, United Kingdom

6. Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom

7. Paediatric Infectious Diseases Research Group, St George's University of London, London, United Kingdom

Abstract

Since 2015 in the United States (US), the US Neisseria meningitidis urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males. Its ‘parent’ strain caused numerous outbreaks of invasive meningococcal disease among men who have sex with men in Europe and North America. We highlight the arrival and dissemination of US_NmUC in the United Kingdom and the emergence of multiple antibiotic resistance. Surveillance systems should be developed that include anogenital meningococci.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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