Under-diagnosis of SARS-CoV-2 infections among children aged 0–15 years, a nationwide seroprevalence study, Israel, January 2020 to March 2021

Author:

Indenbaum Victoria1ORCID,Lustig Yaniv21,Mendelson Ella21,Hershkovitz Yael3,Glatman-Freedman Aharona32,Keinan-Boker Lital43,Bassal Ravit32

Affiliation:

1. Central Virology Laboratory, Ministry of Health, Ramat-Gan, Israel

2. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

3. Israel Center for Disease Control, Ministry of Health, Sheba Medical Center, Ramat-Gan, Israel

4. School of Public Health, University of Haifa, Haifa, Israel

Abstract

Until recently, children and adolescents were not eligible for COVID-19 vaccination. They may have been a considerable source of SARS-CoV-2 spread. We evaluated SARS-CoV-2 IgG antibody seroprevalence in Israeli children aged 0–15 years from January 2020 to March 2021. Seropositivity was 1.8–5.5 times higher than COVID-19 incidence rates based on PCR testing. We found that SARS-CoV-2 infection among children is more prevalent than previously thought and emphasise the importance of seroprevalence studies to accurately estimate exposure.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference18 articles.

1. Long-term symptoms after SARS-CoV-2 infection in children and adolescents.;Radtke;JAMA,2021

2. Attributes and predictors of long COVID.;Sudre;Nat Med,2021

3. A meta-analysis on the role of children in severe acute respiratory syndrome coronavirus 2 in household transmission clusters.;Zhu;Clin Infect Dis,2021

4. The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19.;Almadhi;Int J Infect Dis,2021

5. Isreal Ministry of Health. COVID-19 daily situation report. Ramat-Gan: Isreal Ministry of Health; 2021. [Accessed: 3 Nov 2021]. Available from: https://datadashboard.health.gov.il/COVID-19/general

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