New atypical epidemiological profile of parvovirus B19 revealed by molecular screening of blood donations, France, winter 2023/24

Author:

Guillet Marlène1,Bas Ariane2,Lacoste Marjorie3,Ricard Céline4,Visse Catherine5,Barlet Valérie2,Malard Lucile6,Le Cam Sophie6,Morel Pascal6,de Lamballerie Xavier7,Laperche Syria6,Gallian Pierre76ORCID

Affiliation:

1. Etablissement Français du Sang Centre Pays de Loire, Nantes, France

2. Etablissement Français du Sang Auvergne Rhône Alpes, Lyon Décines, France

3. Etablissement Français du Sang Occitanie, Toulouse, France

4. Etablissement Français du Sang Hauts de France-Normandie, Loos, France

5. LFB – Biomédicaments, Control Laboratories, Courtaboeuf Cedex, France

6. Etablissement Français du Sang, La Plaine Saint-Denis, France.

7. Unité des Virus Émergents (UVE: Aix-Marseille Univ-Corsica Univ-IRD 190-Inserm 1207-IRBA), Marseille, France

Abstract

In France, blood donations are tested in pools of 96 samples for parvovirus B19 (B19V) DNA to discard plasma for fractionation when it contains high viral loads. Between January 2015 and March 2024, B19V-positive donations decreased during the COVID-19 pandemic, followed by a strong rebound in 2023 and unusually high circulation during winter 2023/24 (ca 10 times higher December 2023–March 2024 vs the pre-pandemic period). Variations over time are probably related to measures implemented to limit SARS-CoV-2 spread.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Reference22 articles.

1. Parvovirus B19 viraemia in Dutch blood donors.;Zaaijer;Epidemiol Infect,2004

2. European Centre for Disease Prevention and Control (ECDC). Communicable disease threats report, 14-20 April 2024, week 16. Stockholm: ECDC; 2024. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-14-20-april-2024-week-16

3. Identification and characterization of persistent human erythrovirus infection in blood donor samples.;Candotti;J Virol,2004

4. Persistent infection by human parvovirus B19 in qualified blood donors.;Matsukura;Transfusion,2008

5. Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives.;Sun;PeerJ,2023

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