Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023

Author:

Otto-Knapp Ralf1,Edwards Suzanne2,Kuchukhidze Giorgi3,Kröger Stefan4,Häcker Brit1,Bivol Stela3,Yedilbayev Askar3

Affiliation:

1. German Central Committee against Tuberculosis (DZK), Berlin, Germany

2. Independent Consultant & Department of Healthcare Management, Technical University of Berlin, Berlin, Germany

3. World Health Organization, Regional Office for Europe, Copenhagen, Denmark

4. Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany

Abstract

The BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on national and supranational level are needed to guarantee universal access.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Reference14 articles.

1. World Health Organization (WHO). Global tuberculosis report 2023. Geneva: WHO; 2023. Available from: https://iris.who.int/handle/10665/373828

2. International Union Against Tuberculosis and Lung Disease (The Union). TB among refugees from Ukraine in European countries. Paris: The Union; 2024. Available from: https://theunion.org/news/tb-among-refugees-from-ukraine-in-european-countries

3. The impact of the war in Ukraine on the epidemiological situation of tuberculosis in Europe.;Wilczek;J Clin Med,2023

4. World Health Organization (WHO). WHO consolidated guidelines on tuberculosis. Module 4: treatment - drug-resistant tuberculosis treatment, 2022 update. Geneva: WHO; 2022. Available from: https://iris.who.int/handle/10665/365308

5. Update of drug-resistant tuberculosis treatment guidelines: A turning point.;Vanino;Int J Infect Dis,2023

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