Outbreaks of autochthonous Dengue in Lazio region, Italy, August to September 2023: preliminary investigation

Author:

De Carli Gabriella12,Carletti Fabrizio13,Spaziante Martina2,Gruber Cesare Ernesto Maria3ORCID,Rueca Martina3,Spezia Pietro Giorgio3,Vantaggio Valentina2,Barca Alessandra4,De Liberato Claudio5,Romiti Federico5,Scicluna Maria Teresa6,Vaglio Stefania7,Feccia Mariano8,Di Rosa Enrico9,Gianzi Francesco Paolo10,Giambi Cristina11,Scognamiglio Paola42,Nicastri Emanuele112,Girardi Enrico13,Maggi Fabrizio3,Vairo Francesco2,

Affiliation:

1. These authors contributed equally to this work and share first authorship.

2. Regional Service for Surveillance and Control of Infectious Diseases (SERESMI)-Lazio Region, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy

3. Laboratory of Virology, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy

4. Directorate for Health and Social Policy, Lazio Region, Rome, Italy

5. UOC Diagnostica generale, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Rome, Italy

6. UOC Virologia, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Rome, Italy

7. Lazio Regional Blood Center, Italy; and Department of Molecular Medicine, Sapienza University, Rome, Italy

8. Lazio Regional Transplant Center, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy

9. Department of Prevention, Local Health Authority Roma 1, Rome, Italy

10. Department of Prevention, Local Health Authority Roma 2, Rome, Italy

11. Department of Prevention, Local Health Authority Latina, Latina, Italy

12. Highly Infectious Diseases Isolation Unit, Clinical Department, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy

13. Scientific Direction, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy

Abstract

Between August and September 2023, three distinct autochthonous dengue virus transmission events occurred in Lazio, Italy, with the main event in Rome. The events involved three different dengue serotypes. No link with previous imported cases was identified. Here we describe the epidemiological and phylogenetic analysis of the first autochthonous cases and the implemented control actions. The multiple transmission events call for a strengthening of the vector control strategies and future research to better characterise the risk in countries like Italy.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference14 articles.

1. European Centre for Disease Prevention and Control (ECDC). Autochthonous vectorial transmission of dengue virus in mainland EU/EEA, 2010-present. Stockholm: ECDC. [Accessed: 24 Oct 2023]. Available from: https://www.ecdc.europa.eu/en/all-topics-z/dengue/surveillance-and-disease-data/autochthonous-transmission-dengue-virus-eueea

2. First autochthonous dengue outbreak in Italy, August 2020.;Lazzarini;Euro Surveill,2020

3. Del Manso M, Di Maggio E, Perego G, Petrone D, Mateo-Urdiales A, Caporali MG, et al. Arbovirosi in Italia 2023. [Arboviruses in Italy 2023]. Rome: Instituto Superiore di Sanità. [Accessed: 24 Oct 2023]. Italian. Available from: https://www.epicentro.iss.it/arbovirosi/dashboard

4. A serotype-specific and multiplex PCR method for whole-genome sequencing of dengue virus directly from clinical samples.;Su;Microbiol Spectr,2022

5. Italian Ministry of Health. Piano Nazionale di prevenzione, sorveglianza e risposta alle Arbovirosi (PNA) 2020-2025. [National plan for prevention, surveillance and response to arboviruses 2020-2025]. Rome: Ministry of Health; 2019. Italian. Available from: https://www.salute.gov.it/imgs/C_17_pubblicazioni_2947_allegato.pdf

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