Effectiveness of Omicron XBB.1.5 vaccine against infection with SARS-CoV-2 Omicron XBB and JN.1 variants, prospective cohort study, the Netherlands, October 2023 to January 2024

Author:

Huiberts Anne J1,Hoeve Christina E1,de Gier Brechje1,Cremer Jeroen1,van der Veer Bas1,de Melker Hester E1,van de Wijgert Janneke HHM21,van den Hof Susan1,Eggink Dirk31,Knol Mirjam J31

Affiliation:

1. Centre for Infectious Disease Control, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands

2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (UMCU), Utrecht, the Netherlands

3. These authors contributed equally to this article and share last authorship

Abstract

We estimated vaccine effectiveness (VE) of SARS-CoV-2 Omicron XBB.1.5 vaccination against self-reported infection between 9 October 2023 and 9 January 2024 in 23,895 XBB.1.5 vaccine-eligible adults who had previously received at least one booster. VE was 41% (95% CI: 23–55) in 18–59-year-olds and 50% (95% CI: 44–56) in 60–85-year-olds. Sequencing data suggest lower protection against the BA.2.86 (including JN.1) variant from recent prior infection (OR = 2.8; 95% CI:1.2–6.5) and, not statistically significant, from XBB.1.5 vaccination (OR = 1.5; 95% CI:0.8–2.6).

Publisher

European Centre for Disease Control and Prevention (ECDC)

Reference19 articles.

1. Centers for Disease Control and Prevention (CDC). COVID-19 activity increases as prevalence of JN.1 variant continues to rise. Atlanta: CDC; 2024. Available from: https://www.cdc.gov/respiratory-viruses/whats-new/JN.1-update-2024-01-05.html

2. Covid-19: WHO adds JN.1 as new variant of interest.;Looi;BMJ,2023

3. Virological characteristics of the SARS-CoV-2 JN.1 variant.;Kaku;bioRxiv,2023

4. Protection of COVID-19 vaccination and previous infection against Omicron BA.1, BA.2 and Delta SARS-CoV-2 infections.;Andeweg;Nat Commun,2022

5. Sequencing directly from antigen-detection rapid diagnostic tests in Belgium, 2022: a gamechanger in genomic surveillance?;Rector;Euro Surveill,2023

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3