Transfusion-transmitted hepatitis E in Germany, 2013

Author:

Huzly D1,Umhau M2,Bettinger D3,Cathomen T2,Emmerich F2,Hasselblatt P3,Hengel H1,Herzog R2,Kappert O4,Maassen S4,Schorb E5,Schulz-Huotari C2,Thimme R3,Unmüssig R4,Wenzel J J6,Panning M1

Affiliation:

1. Institute for Virology, University Medical Center, Freiburg, Germany

2. Institute for Cell and Gene Therapy, University Medical Center, Freiburg, Germany

3. Department of Medicine II, University Medical Center, Freiburg, Germany

4. Public Health Office, Freiburg, Germany

5. Department of Medicine I, University Medical Center, Freiburg, Germany

6. Institute of Clinical Microbiology and Hygiene, Regensburg University Medical Center, Regensburg, Germany

Abstract

The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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