The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009-Reference-Cited by-同舟云学术

The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009

Published:2010-04-08 Issue:14 Volume:15 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Harvala H¹,Gunson R²,Simmonds P³,Hardie A¹,Bennett S²,Scott F⁴,Roddie H⁴,McKnight J⁵,Walsh T⁶,Rowney D⁷,Clark A⁸⁷,Bremner J¹,Aitken C²,Templeton K¹

Affiliation:

1. Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

2. West of Scotland Specialist Virology Centre, Glasgow, United Kingdom

3. Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

4. Department of Haematology, Western General Hospital, Edinburgh, United Kingdom

5. Metabolic Unit, Western General Hospital, Edinburgh, United Kingdom

6. Intensive Therapy Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

7. Department of Paediatric Haematology, Royal Hospital for Sick Children, Glasgow, United Kingdom

8. Bone Marrow Transplant Unit, Gartnaval General Hospital, Gartnavel General Hospital, Glasgow, United Kingdom

Abstract

To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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