Genetic aspects of the realization of the severity of the bronchial asthma phenotype in children-Reference-Cited by-同舟云学术

Genetic aspects of the realization of the severity of the bronchial asthma phenotype in children

Published:2024-07-15 Issue:2 Volume:19 Page:85-92
ISSN:1992-6499
Container-title:Astrakhan medical journal
language:
Short-container-title:jour

Author:

Stroykova T. R.¹,Bashkina O. A.¹

Affiliation:

1. Astrakhan State Medical University

Abstract

The study of genes regulating the function of cytokines is an important aspect in the pathogenesis of bronchial asthma, predicting its severity and control. And also, as a result, the implementation of therapeutic approaches for this disease. Interleukin genes have a high degree of polymorphism. The aim of the work was to establish the significance of the effect of polymorphisms of the interleukin genes IL-4 590TC (rs2243250), IL-4RA I50V (rs2243250), TNF-alpha 308AG (rs1800629) on the phenotypic manifestations of the disease. a control group of children consisting of 90 people, patients with bronchial asthma of varying severity – 86 children. The identification of genetic polymorphisms was carried out by PCR. Statistical processing was carried out using the nonparametric chi-square criterion method with the analysis of conjugacy tables. The predictor significance of the homozygous variant of GG and the TNF-alpha allele G rs1800629 in severe disease, as well as the homozygous AG genotype with moderate severity of the disease. Studies of cytokine gene polymorphism in AD contribute to the study of the molecular genetic basis of AD formation and can be used to personalize therapy.

Publisher

Astrakhan State Medical University

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