Affiliation:
1. Saratov State Medical University named after V. I. Razumovsky; Reaviz Medical University
2. Samara State Medical University Samara; Reaviz Medical University
3. Mari State University
Abstract
The purpose of the study – to study the effect of combination therapy, including magnetolaser exposure and the use of photodynamic therapy on the state of matrix metthaloproteinases in acute bacterial prostatitis. Materials and methods. An analysis of the treatment of 30 patients from whom approval was received for conducting a study with an established diagnosis of acute prostatitis of bacterial nature. For this purpose, men aged 18–40 years were selected, the average age was 32 ± 2 years. To conduct the study, the men were divided into three groups of 15 people each. Group 1 included patients who received a combination of antibiotic therapy and magnetic laser therapy as the main treatment. In group 2, patients who received antibiotic therapy and magnetic laser therapy were supplemented with photoditazine at a dose of 0.8 mg/kg per 100 ml. To compare laboratory parameters, a third group (group 3) of 15 relatively healthy men of the same age was formed. To assess the effectiveness of treatment, a dynamic study of metalloproteinase-1 inhibitor (TIMP-1), as well as metalloproteinases (MMPs) -1, -2, -3, -7, -8, -9, into the blood serum. Results. It has been established that the use of photodynamic therapy and laser irradiation of blood in the complex treatment of acute bacterial prostatitis leads to an early recovery of serum MMPs, and as a result, an early relief of signs of inflammation, while the use of this method contributes to a greater number of recoveries, is well tolerated, has a few side effects, which can serve as recommendations for a wider range of the use of this technique in the treatment of acute bacterial prostatitis.
Publisher
Astrakhan State Medical University
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