Author:
BRUCATO ANTONIO,GRAVA CHIARA,BORTOLATI MARIA,IKEDA KEIGO,MILANESI ORNELLA,CIMAZ ROLANDO,RAMONI VERONIQUE,VIGNATI GABRIELE,MARTINELLI STEFANO,SADOU YOUCEF,BORGHI ADELE,TINCANI ANGELA,CHAN EDWARD K.L.,RUFFATTI AMELIA
Abstract
Objective.To study anti-Ro/La-negative congenital heart block (CHB).Methods.Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods.Results.There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers.Conclusion.Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.
Publisher
The Journal of Rheumatology
Subject
Immunology,Immunology and Allergy,Rheumatology
Cited by
24 articles.
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