Author:
SU HAIXIANG,BARON MURRAY,BENARROCH MICHAEL,VELLY ANA M.,GRAVEL SABRINA,SCHIPPER HYMAN M.,GORNITSKY MERVYN
Abstract
Objective.Oxidative stress has been implicated in the pathogenesis of systemic sclerosis (SSc). Our objective was to determine whether SSc is associated with altered redox homeostasis in human saliva.Methods.Study participants were 70 women with SSc and 120 female controls. 8-hydroxy-2’-deoxyguanosine (8-OHdG), 8-epi-prostaglandin F 2α (8-epi-PGF2α), and total protein carbonyls were assayed by ELISA to quantify oxidative damage to nucleic acids, lipids, and proteins, respectively, in whole nonstimulated saliva.Results.We observed a significantly positive association between salivary log protein carbonyls and SSc in a crude statistic (OR 9.06, p < 0.0001), and multivariable model adjusted for log 8-OHdG, log 8-epi-PGF2α, and antioxidant exposure (OR 9.26, p < 0.0001). No significant association was noted between SSc and salivary log 8-epi-PGF2α or log 8-OHdG.Conclusion.Salivary redox homeostasis is perturbed in patients with SSc and may inform on the pathophysiology and presence of the disease (biomarkers) and efficacy of therapeutic interventions.
Publisher
The Journal of Rheumatology
Subject
Immunology,Immunology and Allergy,Rheumatology
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献