Evaluation of Tag Single-Nucleotide Polymorphisms for Identifying HLA-B27 Status in a Chinese Han Population
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Published:2022-12-15
Issue:
Volume:
Page:jrheum.220958
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ISSN:0315-162X
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Container-title:The Journal of Rheumatology
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language:en
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Short-container-title:J Rheumatol
Author:
Sheng Nan,
Wang Wenwen,
Zhang Bo,
Zhao Jingjing,
Chen Haojie,
Feng PanfengORCID,
Gao YingyingORCID,
Chen XiaoxiangORCID
Abstract
Ankylosing spondylitis (AS) often presents with an insidious onset and is difficult to be distinguished from other arthritis.1Due to the strong association between AS and HLA-B27,2identifying HLA-B27 status is of great significance for assisting diagnosis in clinical practice. Compared with common methods for detecting HLA-B27 (eg, flow cytometry and HLA-B27 sequence detection methods), tag single-nucleotide polymorphisms (tag-SNPs) for HLA-B27 could readily infer HLA-B27 positivity according to the presence of 1 allele of tag-SNP (eg, the T allele for the rs116488202 SNP),3suggesting a convenient strategy for identifying HLA-B27 status.
Publisher
The Journal of Rheumatology
Subject
Immunology,Immunology and Allergy,Rheumatology