Author:
Singh Jasvinder A.,Taylor William J.,Dalbeth Nicola,Simon Lee S.,Sundy John,Grainger Rebecca,Alten Rieke,March Lyn,Strand Vibeke,Wells George,Khanna Dinesh,McQueen Fiona,Schlesinger Naomi,Boonen Annelies,Boers Maarten,Saag Kenneth G.,Schumacher H. Ralph,Edwards N. Lawrence
Abstract
Objective.To determine the extent to which participants at the Outcome Measures in Rheumatology (OMERACT) 11 meeting agree that instruments used in clinical trials to measure OMERACT core outcome domains in acute gout fulfill OMERACT filter requirements of truth, discrimination, and feasibility; and where future research efforts need to be directed.Methods.Results of a systematic literature review and analysis of individual-level data from recent clinical studies of acute gout were presented to OMERACT participants. The information was discussed in breakout groups, and opinion was defined by subsequent voting in a plenary session. Endorsement was defined as at least 70% of participants voting in agreement with the proposition (where the denominator excluded those participants who did not vote or who voted “don’t know”).Results.The following measures were endorsed for use in clinical trials of acute gout: (1) 5-point Likert scale and/or visual analog scale (0 to 100 mm) to measure pain; (2) 4-point Likert scale for joint swelling; (3) 4-point Likert scale for joint tenderness; and (4) 5-point Likert scale for patient global assessment of response to treatment. Measures for the activity limitations domain were not endorsed.Conclusion.Measures of pain, joint swelling, joint tenderness, and patient global assessment in acute gout were endorsed at OMERACT 11. These measures should now be used in clinical trials of acute gout.
Publisher
The Journal of Rheumatology
Subject
Immunology,Immunology and Allergy,Rheumatology
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Prednisolone Versus Colchicine for Acute Gout in Primary Care (COPAGO): protocol for a two-arm multicentre, pragmatic, prospective, randomized, double-blind, controlled clinical trial of prednisolone and colchicine for non-inferiority with a parallel group design;Trials;2023-10-05
2. Prednisolone Versus Colchicine for Acute Gout in Primary Care (COPAGO). Protocol for a two-arm multicentre, pragmatic, prospective, randomised, double-blind, controlled clinical trial of prednisolone and colchicine for non-inferiority with a parallel group design.;2023-09-13
3. Interleukin-1β inhibitors for the management of acute gout flares: a systematic literature review;Arthritis Research & Therapy;2023-07-25
4. Outcome reporting in randomized trials in gout: A systematic scoping review from the OMERACT gout working group assessing the uptake of the core outcome set;Seminars in Arthritis and Rheumatism;2023-06
5. The challenge of gout flare measurement;Best Practice & Research Clinical Rheumatology;2021-12